COVID-19

questions and ideas
Resveratrol, a well known stilbenoid compound, could be investigated by medical professionals for activity against COVID-19

Scientists should do a trial on resveratrol as an adjunct to COVID-19 treatment. Studies I have read make me think that it might be helpful- from what I know about the disease. But research is needed. So even though resveratrol is generally quite safe, in healthy people, and ameliorates sepsis, and pulmonary fibrosis, is sometimes neuroprotective, opens the airway in other similar conditions, BUT don't get me wrong, there is an unknown, probably small but real chance that it could also be detrimental in SARS-CoV-2 patients. WE DON'T KNOW.

N-Acetyl-Cysteine, an amino acid nutritional supplement, could be investigated in fighting the COVID-19 epidemic

NAC as it is called is a food and the most important of several precursors of an important chemical in your body, glutathione. Along with glutamine, it may improve gut barrier function. and regardless, it is unlikely to hurt anything. It's proven itself very useful in colds where its sold in effervescent tablets for that use in Europe. They are popular. The highest natural source of cysteine is whey protein.

Antiviral Strategies Against Human Coronaviruses

Abstract: Since the mid 60’s the human coronaviruses (HCoV), represented by HCoV-OC43 and HCoV-229E, were generally considered relatively harmless viruses. This status changed dramatically with the emergence of SARS-CoV in 2002/2003. The SARS- CoV pandemic took 774 lives around the globe and infected more than 8000 people in 29 countries. SARS-CoV is believed to be of zoonotic origin, transmitted from its natural reservoir in bats through several animal species (e.g., civet cats, raccoon dogs sold for human consumption in markets in southern China). The epidemic was halted in 2003 by a highly effective global public health response, and SARS-CoV is currently not circulating in humans. The outbreak of SARS-CoV and the danger of its re-introduction into the human population, as well as the danger of the emergence of other zoonotic coronaviral infections triggered an intense survey for an efficient treatment that resulted in the evaluation of several anticoronaviral compounds. HCoV-NL63 and HCoV-HKU1 were identified shortly after the SARS-CoV outbreak. The 4 human coronaviruses HCoV-229E, HCoV- OC43, HCoV-NL63 and HCoV-HKU1 cause mild respiratory illnesses when compared to SARS, but these infections are involved in 10 – 20 % of hospitalizations of young children and immunocompromised adults with respiratory tract illness. Therefore, there is an urgent need for a successful therapy to prevent disease induction or a vaccine to prevent new infections. This review summarizes the current status of anticoronaviral strategies.

US has potential of becoming coronavirus epicentre, says WHO

WHO spokeswoman Margaret Harris said in Geneva there had been a "very large acceleration" in coronavirus infections in the United States which had the potential of becoming the new epicenter. Over the past 24 hours, 85 percent of new cases were from Europe and the United States, she told reporters. Of those, 40 percent were from the United States. Asked whether the United States could become the new epicenter, Harris said: "We are now seeing a very large acceleration in cases in the U.S. So it does have that potential. We cannot say that is the case yet but it does have that potential." ------------------------------------------- (Source: VOA https://www.voanews.com/science-health/coronavirus-outbreak/us-could-become-coronavirus-epicenter-who-says )

The Virus Can Be Stopped, but Only With Harsh Steps, Experts Say

Scientists who have fought pandemics describe difficult measures needed to defend the United States against a fast-moving pathogen. "If it were possible to wave a magic wand and make all Americans freeze in place for 14 days while sitting six feet apart, epidemiologists say, the whole epidemic would sputter to a halt. The virus would die out on every contaminated surface and, because almost everyone shows symptoms within two weeks, it would be evident who was infected. If we had enough tests for every American, even the completely asymptomatic cases could be found and isolated. The crisis would be over."

CDC: Severe Outcomes Among Patients with Coronavirus Disease 2019 (COVID-19) — United States, February 12–March 16, 2020

What this tells us is that nobody is immune from getting COVID-19 and potential hospitalization, which in the US is astronomically expensive. "California on Tuesday reported the first death in the United States of a Covid-19 patient younger than 18, and the family of a 12-year-old in Georgia said Sunday she was on a ventilator and fighting for her life in an Atlanta hospital. There also have been "concerning reports from France and Italy" about young people becoming seriously ill, "and very seriously ill in the ICUs," said Dr. Deborah Birx, the White House's coronavirus reponse coordinator, last week. There are now more than 52,000 cases of the virus in the United States. At least 680 people had died as of Tuesday afternoon." (Source CNN)

Drug Companies Will Make a Killing From Coronavirus Unless we fix the system, American taxpayers will get gouged on a vaccine they paid to produce.

Opinion Drug Companies Will Make a Killing From Coronavirus Unless we fix the system, American taxpayers will get gouged on a vaccine they paid to produce. By Mariana Mazzucato and Azzi Momenghalibaf Ms. Mazzucato is a professor at University College London and the author of “The Value of Everything.” Ms. Momenghalibaf is a senior program officer at the Open Society Public Health Program. https://www.nytimes.com/2020/03/18/opinion/coronavirus-vaccine-cost.html

Trump's Indadequate Response

Mr. Trump is known for undermining scientists, institutions and the media. He shut down the White House National Security Council’s entire global health security unit in 2018, an error that is perhaps going to cost him dearly now. He can only sincerely hope that “one day, it’s like a miracle, it will disappear”.