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Potential therapeutic effects of Resveratrol against SARS-CoV-2

Home Acta Virologica 2020 Acta Virologica Vol.64, No.3, p.276-280, 2020 --- Novel Coronavirus COVID-19 or Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as well as Severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), are human pathogens. Current pandemics of SARS-CoV-2 represents a major health problem worldwide, with over four million cases and more than 300,000 deaths in the world. Development of effective therapy thus became an emergency. This report aims to highlight Resveratrol as possible therapeutic candidate in SARS-CoV-2 infection. The antiviral efficacy of Resveratrol was demonstrated for several viruses, including coronavirus. Resveratrol was shown to mitigate the major pathways involved in the pathogenesis of SARS-CoV-2, including regulation of the renin-angiotensin system (RAS) and expression of angiotensin-converting enzyme 2 (ACE2), stimulation of immune system and downregulation of pro-inflammatory cytokines release. It was also reported to promote SIRT1 and p53 signaling pathways and increase cytotoxic T lymphocytes (CTLs) and natural killer (NK) immune cells. In addition, Resveratrol was demonstrated to be a stimulator of fetal hemoglobin and a potent antioxidant, by trapping reactive oxygen species (ROS). According to these reports, Resveratrol could be proposed as potential therapeutics in the treatment of SARS-CoV-2. Keywords: SARS-CoV-2; Resveratrol; antiviral activity; immune response; ACE2; oxidative stress; HbF.

Medical journal article shows several key aspects of RESV and virus inhibition against another highly virulent virus in pigs.

Antiviral properties of resveratrol against pseudorabies virus are associated with the inhibition of IκB kinase activation. (Note, this study is not about COVID-19 directly, however its illustrative of how RESV can work to prevent and/or atetnuate a much more pathogenic virus that infects the brain in a way that is relevant to COVID-19, when we consider that RESV has similarly been shown to inhibit the SARS-CoV-2 virus (as well as MERS and SARS-CoV-1) in vitro, in the lab.

Resveratrol was predicted to have possible activity against COVID-19 by a cutting edge medical informatics program looking for substances active against coronavirus induced heart damage.

Exploration of omics mechanism and drug prediction of coronavirus-induced heart failure based on clinical bioinformatics. --------------------- Objective: Present study investigated the mechanism of heart failure associated with coronavirus infection and predicted potential effective therapeutic drugs against heart failure associated with coronavirus infection. KEYWORDS: Bioinformatics; Coronavirus infections; Drug prediction; Heart failure PMID: 32228827 DOI: 10.3760/cma.j.cn112148-20200308-00172

N-Acetyl-Cysteine, an amino acid nutritional supplement, could be investigated in fighting the COVID-19 epidemic

NAC as it is called is a food and the most important of several precursors of an important chemical in your body, glutathione. Along with glutamine, it may improve gut barrier function. and regardless, it is unlikely to hurt anything. It's proven itself very useful in colds where its sold in effervescent tablets for that use in Europe. They are popular. The highest natural source of cysteine is whey protein.