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Therapeutic blockade of inflammation in severe COVID-19 infection with intravenous N-acetylcysteine

Glucose 6-phosphate dehydrogenase (G6PD) deficiency facilitates human coronavirus infection due to glutathione depletion. G6PD deficiency may especially predispose to hemolysis upon coronavirus disease-2019 (COVID-19) infection when employing pro-oxidant therapy. However, glutathione depletion is reversible by N-acetylcysteine (NAC) administration. We describe a severe case of COVID-19 infection in a G6PD-deficient patient treated with hydroxychloroquine who benefited from intravenous (IV) NAC beyond reversal of hemolysis. NAC blocked hemolysis and elevation of liver enzymes, C-reactive protein (CRP), and ferritin and allowed removal from respirator and veno-venous extracorporeal membrane oxygenator and full recovery of the G6PD-deficient patient. NAC was also administered to 9 additional respirator-dependent COVID-19-infected patients without G6PD deficiency. NAC elicited clinical improvement and markedly reduced CRP in all patients and ferritin in 9/10 patients. NAC mechanism of action may involve the blockade of viral infection and the ensuing cytokine storm that warrant follow-up confirmatory studies in the setting of controlled clinical trials. Keywords: Coronavirus 19, COVID-19, N-acetylcysteine, Glutathione, Glucose 6-phosphate dehydrogenase, Mechanistic target of rapamycin, C-reactive protein, Ferritin, Respirator, Extracorporeal membrane oxygenation

Potential therapeutic effects of Resveratrol against SARS-CoV-2 (COVID-19)

"This report aims to highlight Resveratrol as possible therapeutic candidate in SARS-CoV-2 infection. The antiviral efficacy of Resveratrol was demonstrated for several viruses, including coronavirus. Resveratrol was shown to mitigate the major pathways involved in the pathogenesis of SARS-CoV-2, including regulation of the renin-angiotensin system (RAS) and expression of angiotensin-converting enzyme 2 (ACE2), stimulation of immune system and downregulation of pro-inflammatory cytokines release. It was also reported to promote SIRT1 and p53 signaling pathways and increase cytotoxic T lymphocytes (CTLs) and natural killer (NK) immune cells. In addition, Resveratrol was demonstrated to be a stimulator of fetal hemoglobin and a potent antioxidant, by trapping reactive oxygen species (ROS). According to these reports, Resveratrol could be proposed as potential therapeutics in the treatment of SARS-CoV-2. " Keywords: SARS-CoV-2; Resveratrol; antiviral activity; immune response; ACE2; oxidative stress; HbF. -- Acta Virol . 2020 Sep 28. doi: 10.4149/av_2020_309. Online ahead of print.

ip-health mailing list Archives

Discussions of Intellectual Property and Health Care "To see the collection of prior postings to the list, visit the Ip-health Archives." This is one of the very best places to learn about the battle -access to medicines vs drug patents and the drug cartel. If you saw the film "Fire in the Blood" you saw how, in this era of global epidemics and corporate greed people must stand up for the rights of human beings to lifesaving drugs at affordable and not extortionate prices. This URL brings one straight to the list archives.

Resveratrol was predicted to have possible activity against COVID-19 by a cutting edge medical informatics program looking for substances active against coronavirus induced heart damage.

Exploration of omics mechanism and drug prediction of coronavirus-induced heart failure based on clinical bioinformatics. --------------------- Objective: Present study investigated the mechanism of heart failure associated with coronavirus infection and predicted potential effective therapeutic drugs against heart failure associated with coronavirus infection. KEYWORDS: Bioinformatics; Coronavirus infections; Drug prediction; Heart failure PMID: 32228827 DOI: 10.3760/cma.j.cn112148-20200308-00172

UPDATED WITH WARNING: French study shows hydroxychloroquine sulfate, for 10 days + azithromycin clears 97% of patients of virus. But may cause potentially dangerous cardiac arrhythmia if not taken under close supervision by MDs.

(Note: This drug may cause cardiac arrhythmia!) Both of these drugs are only available with a prescription and should only be taken under a doctors supervision. ---In the French study, patients were given a combination of 200 milligrams of oral hydroxychloroquine sulfate, three times a day for 10 days, combined with azithromycin. Five hundred milligrams of the (azithromycin) was given to patients on day one, followed by 250 milligrams per day over the next four days. Virus cultures taken from patient’s respiratory samples were negative in 97.5 percent of patients at day 5, allowing the rapid discharge of patients from highly contagious hospital wards, the researchers wrote in the study. This is this French infectious disease institute's second study of this two drug combination.