Articles

The COVID-19 situation illustrates why trade agreements should never have been used to hijack the peoples wishes to lock in bad policy on healthcare and drugs, trapping politicians in big lies.

Most Americans mistakenly believe we can just vote to fix these things, and solve them. Unfortunately, its not so easy. We've been misled by the people in high places, and the media. The fact is the government now has intentionally created a system to TIE ITS OWN HANDS, locking out all progressive change, it hopes, forever. Showing how Its so very confident of its ability to pull the wool over our eyes, indefinitely.

WHO announces COVID-19 Technology Pool to cooperate to beat the virus.

Countries from around the world are joining to pool their resources to stop COVID-19 and make the world safe again.

Trump confesses he doesn't want to do testing in the US because it reveals cases of COVID-19.

“When you test, you have a case. When you test, you find something is wrong with people. If we didn’t do any testing we would have very few cases.”

It's still way too early to "open the US up" say the numbers.

It seems that if you remove the NYC metro area from the graphs, the infections in the rest of the US are still rising a lot. So many areas have not even been touched by the virus, yet. This is from an interesting looking site on coronavirus risk reduction..

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Orally delivered resveratrol-loaded lipid-core nanocapsules ameliorate LPS-induced acute lung injury via the ERK and PI3K/Akt pathways

Nanoencapsulated resveratrol used to successfully treat ALI and ARDS caused by LPS.

Anti-inflammatory effect of resveratrol in human coronary arterial endothelial cells via induction of autophagy: implication for the treatment of Kawasaki disease.

NOTE: Its not known if these effects would translate to beneficial effects in COVID-19 at all. Please don't think it's known if it would or would not, it's not. ------ Kawasaki disease (KD) is an acute febrile vasculitis in childhood, which is the leading cause of acquired heart disease in children. If untreated, KD can result in coronary aneurysms in 25% of patients, and even under intravenous immunoglobulin (IVIG) treatment, 10-20% of children will have IVIG resistance and increased risk of developing coronary arteritis complication. Additional therapies should be explored to decrease the incidence of coronary artery lesions and improve the prognosis in KD. Autophagy has been reported to play a critical role in a variety of heart diseases. Resveratrol (RSV) confers cardio protection during ischemia and reperfusion in rats via activation of autophagy. Serum TNF-alpha levels are elevated in KD, which might activate the endothelial cells to express intercellular adhesion molecule-1 (ICAM-1), vascular cellular adhesion molecule-1(VCAM-1), inducible nitric oxide synthase (iNOS) and IL-1β. METHODS: Human coronary arterial endothelial cells (HCAECs) were either untreated or treated by TNF-α 10 ng/ml for 2 h in the presence or absence of RSV or autophagy-related protein 16-like 1 (Atg16L1) siRNA. Total RNA was analyzed by real-time quantitative PCR for ICAM-1, VCAM-1, iNOS and IL-1β mRNA expressions. The involvement of autophagy proteins was investigated by Western blot. RESULTS: Pretreatment with resveratrol significantly inhibited TNF-α-induced ICAM-1, iNOS and IL-1β mRNA expression in HCAECs. Western blot revealed the enhanced autophagy proteins LC3B and Atg16L1 expression by RSV. The suppressive effects of RSV were obviously counteracted by Atg16L1 siRNA. CONCLUSIONS: We demonstrated RSV had anti-inflammatory effects on HCAECs via induction of autophagy. Our results suggest that resveratrol may modulate the inflammatory response of coronary artery in KD and explore the role of autophagy in the pathogenesis and alternative therapy of coronary arterial lesions in KD. KEYWORDS: Autophagy; Endothelial cells; Kawasaki disease; Resveratrol PMID: 28069066 PMCID: PMC5223384 DOI: 10.1186/s40360-016-0109-2

Somebody else puts forward NAC as a potential aid for COVID-19

screen shot from Medical Hypothesis (journal)