Articles

Insurance Industry position paper on TISA contains good explanation of the sticky issues facing Biden especially's promise to "maintain" pre-existing conditions protection that may never have been compliant to GATS

Ten years ago, the Obama Administration's "Affordable Care Act" as proposed and enacted then, likely breached the US's own Understanding on Commitments in Financial Services which required a "standstill" of financial services regulation as of its signing date, February 26, 1998.

The dangers of rushing coronavirus vaccines are substantial.

Because some Middle East respiratory syndrome (MERS) and SARS-CoV-1 vaccines have shown evidence of disease enhancement in some animal models, this phenomenon is a major concern for vaccine development.

Medicare and Social Security: Biden and Trump are poison for these programs. They are setting up traps for the unwary

URGENT: Both US Presidential candidates have plans to make changes to our current Medicare and Social Security systems. But because of little known WTO rules,. changes of any kind - apart from leaving GATS, first, are both extremely ill advised. GATS COMMITMENTS PUT ALL PUBLIC SERVICES ON A FAST TRACK TO PRIVATIZATION THAT RATCHETS IN. GATS MUST BE LEFT NOW. As things are now, touching either of these programs in any way is very likely to destroy them. Also, the term "Medicare for All" should not be used because unless we leave GATS, via the Article XXI procedure, expanding Medicare to be any larger in scope than simply for the retired already in our social security system, will put it in grave danger, killing its ability to receive a subsidy sustainably. This is easy to show simply by reading the Annex on Financial services first paragraph, and tracing out what it means by looking up the literature on the pieces and definitions referred to. Don't trust either candidate because they can only further alienate our rights, not return us to the past when we could regulate these areas we committed in 1994 or even earlier. THAT'S WHAT TRADE AGREEMENTS DO. We're being subjected to a collossal scam, whose goal is to strip the American people of everything that makes it possible to live as a working person in this country. They are trading away our jobs and democracy. We're being run by crooks like never before and I mean both parties. Its been this way for a long time but the situation is progressively getting worse because that's what the GATS and other trade agreements we helped make this way do. There is no way to sugar coat this. Additionally, people should be aware that Bernie Sanders proposals had in fact all been taken off the table by the signing of the GATS in 1994, so he did the country a great disservice by not telling the country at all about GATS. In fact his advice - to vote for Biden in the context of failing to bring up the need to get out of GATS is very bad advice unless Biden literally promises to start the rocess to get out of GATS and not sign any additional trade deals and indeed get out of all trade deals that limit our regulatory freedom, as literally the first act he does, and agrees to resign immediately and call another election if he fails to do so. But of course such a promise would be unenforceable. People we are in a dire situation. We screwed up terribly by allowing our country to be taken over by the cabal of global oligarchs who want to trade away millions of decent jobs to the lowest bidding firms in the lowest paid countries. That is one of GATS goals, another is literally privatizing everything and ending government subsidies on areas where there are market failures, instead they want poor people to go to poor countries. Even as their jobs are being traded away and they are losing their homes and livelihoods.

The COVID-19 situation illustrates why trade agreements should never have been used to hijack the peoples wishes to lock in bad policy on healthcare and drugs, trapping politicians in big lies.

Most Americans mistakenly believe we can just vote to fix these things, and solve them. Unfortunately, its not so easy. We've been misled by the people in high places, and the media. The fact is the government now has intentionally created a system to TIE ITS OWN HANDS, locking out all progressive change, it hopes, forever. Showing how Its so very confident of its ability to pull the wool over our eyes, indefinitely.

ncovitems

Endogenous Deficiency of Glutathione as the Most Likely Cause of Serious Manifestations and Death in COVID-19 Patients

Higher rates of serious illness and death from coronavirus SARS-CoV-2 (COVID-19) infection among older people and those who have comorbidities suggest that age- and disease-related biological processes make such individuals more sensitive to environmental stress factors including infectious agents like coronavirus SARS-CoV-2. Specifically, impaired redox homeostasis and associated oxidative stress appear to be important biological processes that may account for increased individual susceptibility to diverse environmental insults. The aim of this Viewpoint is to justify (1) the crucial roles of glutathione in determining individual responsiveness to COVID-19 infection and disease pathogenesis and (2) the feasibility of using glutathione as a means for the treatment and prevention of COVID-19 illness. The hypothesis that glutathione deficiency is the most plausible explanation for serious manifestation and death in COVID-19 patients was proposed on the basis of an exhaustive literature analysis and observations. The hypothesis unravels the mysteries of epidemiological data on the risk factors determining serious manifestations of COVID-19 infection and the high risk of death and opens real opportunities for effective treatment and prevention of the disease. The novel coronavirus SARS-CoV-2 (COVID-19) continues to spread throughout the globe, affecting more and more people; thus, the identification of effective drugs for disease prevention and treatment is necessary. The overwhelming majority of people infected by SARS-CoV-2 have asymptomatic, mild, or moderate disease, and only 14% and 5% of patients developed severe or critical disease, respectively.1 Higher rates of serious illness and death from COVID-19 infection among older people and those who have comorbidities suggest that age- and disease-related biological processes make such individuals more sensitive to environmental stress factors including infectious agents like coronavirus SARS-CoV-2. Specifically, impaired redox homeostasis and associated oxidative stress appear to be important biological processes that may account for increased individual susceptibility to diverse environmental insults. Oxidative stress is a nonspecific pathological condition reflecting an imbalance between the increased production of reactive oxygen species (ROS) and an inability of biological systems to detoxify the reactive intermediates or to repair the resulting damage.2 Notably, ROS are closely related with aging because they mediate a stress response to age-dependent damage.3 Mounting evidence supports the concept that oxidative stress and associated inflammation resulting from an increased production of ROS and/or decreased antioxidant defense contribute to the pathogenesis of various chronic diseases,4 including diabetes and cardiovascular and respiratory diseases, known to increase the risk of severe illness and death in COVID-19 patients.5 It is also known that virus-induced modulation of the host antioxidant response represents a crucial determinant for the progression of several viral diseases.6 In this regard, the antioxidant defense system protecting against oxidative stress is of great interest in the context of understanding the mechanisms underlying nonspecific sensitivity or resistance to infectious agents. Glutathione (a tripeptide consisting of cysteine, glycine, and glutamate) is the most abundant molecular weight antioxidant that plays a crucial role in antioxidant defense against oxidative damage of cells from ROS and is also involved in the regulation of various metabolic pathways essential for whole body homeostasis.7 The maintenance of the highest (millimolar) concentrations of reduced glutathione (GSH) in most cell types highlights its vital and multifunctional roles in the control of various biological processes such as detoxification of foreign and endogenous compounds, protein folding, regeneration of vitamins C and E, maintenance of mitochondrial function, antiviral defense, regulation of cellular proliferation, apoptosis, and immune response.7 Despite a number of publications reporting beneficial effects of glutathione on human health, the key role of this powerful antioxidant in human physiology and pathology and in clinical applications still remains underestimated. The aim of this Viewpoint is to justify (1) the crucial roles of glutathione in determining individual responsiveness to COVID-19 infection and disease pathogenesis and (2) the feasibility of using glutathione as a means for the treatment and prevention of COVID-19 illness.

The Role of Glutathione in Protecting against the Severe Inflammatory Response Triggered by COVID-19

The novel COVID-19 pandemic is affecting the world’s population differently: mostly in the presence of conditions such as aging, diabetes and hypertension the virus triggers a lethal cytokine storm and patients die from acute respiratory distress syndrome, whereas in many cases the disease has a mild or even asymptomatic progression. A common denominator in all conditions associated with COVID-19 appears to be the impaired redox homeostasis responsible for reactive oxygen species (ROS) accumulation; therefore, levels of glutathione (GSH), the key anti-oxidant guardian in all tissues, could be critical in extinguishing the exacerbated inflammation that triggers organ failure in COVID-19. The present review provides a biochemical investigation of the mechanisms leading to deadly inflammation in severe COVID-19, counterbalanced by GSH. The pathways competing for GSH are described to illustrate the events concurring to cause a depletion of endogenous GSH stocks. Drawing on evidence from literature that demonstrates the reduced levels of GSH in the main conditions clinically associated with severe disease, we highlight the relevance of restoring GSH levels in the attempt to protect the most vulnerable subjects from severe symptoms of COVID-19. Finally, we discuss the current data about the feasibility of increasing GSH levels, which could be used to prevent and subdue the disease. Keywords: SARS-CoV-2, angiotensin-converting enzyme (ACE), angiotensin-converting enzyme 2 (ACE2), glutathione, inflammation, ROS, N-acetylcysteine, NAC, glycine.

Orally delivered resveratrol-loaded lipid-core nanocapsules ameliorate LPS-induced acute lung injury via the ERK and PI3K/Akt pathways

Nanoencapsulated resveratrol used to successfully treat ALI and ARDS caused by LPS.